[Videofluorographic evaluation of dysphagia in a patient with myasthenia gravis].

Abstract

A 64-year-old woman with myasthenia gravis (MG) presented with isolated bulbar symptoms. Two years earlier, she had developed neck weakness, diplopia, and ptosis and was diagnosed with MG. Extensive thymectomy was performed, and she was treated with predonisolone (PSL). The neck weakness, diplopia, and ptosis improved over a 2-year period. However, dysphagia developed, and her voice took on a nasal tone that did not improve subjectively even after administration of 10 mg of edrophonium chloride (EC). We then performed videofluorography (VF). After consumption of 10 ml of liquid barium and 8 g of corned beef hash, she attempted to swallow, but the residue remained in the valleculae and the piriform fossa. After the EC injection, her dysphagia on ingestion of corned beef hash improved; however, there was slight subjective improvement in swallowing. Drinking of liquid barium resulted in some residue with slight improvement of dysphagia. After treatment with 70 mg of PSL for 4 weeks, VF showed improvement of dysphagia. Thus, VF, particularly during consumption of solid food, with EC administration is helpful in evaluating bulbar symptoms in patients with MG.

• Authors: Yoshitsugu Aoki, Toshiyuki Yamamoto, Katsuhisa Ogata, Yasushi Oya, Masafumi Ogawa, Miho Murata
• Journal: Rinsho shinkeigaku = Clinical neurology (Rinsho Shinkeigaku) Vol. 47 Issue 10 Pg. 669-71 (Oct 2007) ISSN: 0009-918X [Print] Japan
• PMID: 18095502 (Publication Type: Case Reports, Journal Article)

Chemical References

• Barium
• Edrophonium

Topics

• Barium
• Deglutition
• Deglutition Disorders (diagnostic imaging, etiology, physiopathology)
• Edrophonium
• Female
• Fluoroscopy (methods)
• Humans
• Middle Aged
• Myasthenia Gravis (complications)
• Videotape Recording