| Abstract | In this study we determine the effects of reducing blood glucose on mean arterial blood pressure (MAP) and hematocrit (Hct) in patients with type 2 diabetes who are not responding to conventional treatment in an intensive treatment program 1 year after initiation of treatment. Data on MAP, glucose and Hct was obtained from 21 diabetic type 2 individuals subjected to personalized treatment and compared (paired statistics) to pretreatment conditions. Exclusion criteria were severe retinopathy, diabetic nephropathy, amputation of diabetic foot and increased glucose>50 mg/dl. Treatment was the combined administration of glibenclamide and metformin dosed to obtain a reduction of glucose levels. Exercise and strict adherence to a prescribed diet were prescribed in all cases. One year after initiation of therapy, glucose decreased from 219 +/- 87 to 158+/-51 mg/dl (p<0.002), Hct increased from 41.6 +/- 3.2 to 44.7+/-2.9% (p<0.001) and MAP decreased from 100.6 +/- 11.0 to 94.3+/-7.2 mmHg (p<0.001). There were no statically significant changes in cholesterol and triglyceride concentrations. The patients lost weight (72.5+/-12.6 to 70.3+/-13.0 kg, p<0.001) and lowered blood creatinine concentration from 1.04+/-0.24 to 0.95+/-0.25 mg/dl, p<0.05. The increase in Hct should correspond to an increase in blood viscosity of about 12%, however blood pressure, and presumably vascular resistance, decreased by 6%. It is proposed that these effects are in part related to improved kidney function resulting in increased Hct and blood viscosity which increases vascular wall shear stress and NO bioavailability leading to a vasodilator effect. |
| Authors | Beatriz Y Salazar Vázquez, Miguel A Salazar Vázquez, Verónica Covarrubias Venzor, Adolfo Chávez Negrete, Pedro Cabrales, Jesús Sida Díaz, Marcos Intaglietta
(Affiliation: Faculty of Medicine, Universidad Juárez del Estado de Durango, Durango, México.)
|
| Journal | Clinical hemorheology and microcirculation
(Clin Hemorheol Microcirc)
Vol. 38
Issue 1
Pg. 57-64
( 2008)
ISSN: 1386-0291 Netherlands |
| PMID | 18094460
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Blood Glucose
- Glyburide
- Creatinine
- Metformin
|
| Topics |
- Blood Glucose
(drug effects)
- Blood Pressure
(drug effects)
- Creatinine
(blood)
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(drug therapy)
- Drug Therapy, Combination
- Female
- Glyburide
(therapeutic use)
- Hematocrit
- Humans
- Male
- Metformin
(therapeutic use)
- Salvage Therapy
- Weight Loss
|
