| Abstract | Pick disease (PiD) is a frontotemporal dementia characterized by frontal and temporal atrophy, neuronal loss, gliosis, ballooned neurons that are positive for alpha-B crystallin and neurofilament, and the presence of tau- and ubiquitin-positive Pick bodies. TAR-DNA binding protein 43 (TDP-43) has been found to be a component of ubiquitinated inclusions in other neurodegenerative diseases, including frontotemporal lobar degeneration with ubiquitinated inclusions and amyotrophic lateral sclerosis. Fifteen cases of PiD were examined using immunohistochemical methods, and 5 cases with both Pick bodies and smaller intracytoplasmic inclusions that showed staining for ubiquitin, tau, and TDP-43 were observed. The presence of TDP-43 inclusions in PiD suggests that TDP-43 accumulation may be an important component of many neurodegenerative diseases, and that its presence in only some cases of PiD may indicate different pathways of disease development. |
| Authors | Stefanie H Freeman, Tara Spires-Jones, Bradley T Hyman, John H Growdon, Matthew P Frosch
(Affiliation: Department of Pathology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA. sfreeman1 at partners.org)
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| Journal | Journal of neuropathology and experimental neurology
(J Neuropathol Exp Neurol)
Vol. 67
Issue 1
Pg. 62-7
(Jan 2008)
ISSN: 0022-3069 United States |
| PMID | 18091558
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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| Chemical References |
- DNA-Binding Proteins
- Ubiquitin
- protein TDP-43
- tau Proteins
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| Topics |
- Aged
- Aged, 80 and over
- Brain
(metabolism, pathology)
- Case-Control Studies
- DNA-Binding Proteins
(metabolism)
- Female
- Humans
- Intranuclear Inclusion Bodies
(metabolism)
- Male
- Middle Aged
- Neurons
(metabolism, pathology)
- Pick Disease of the Brain
(metabolism, pathology)
- Ubiquitin
(metabolism)
- tau Proteins
(metabolism)
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