Abstract | OBJECTIVE: METHODS: Patients with brain metastases from breast cancer were randomly assigned to receive WBRT and either efaproxiral or no efaproxiral. The primary endpoint for this analysis was quality of life and quality-adjusted survival. Quality of life was assessed prior to initiation of WBRT and periodically in follow-up using the Spitzer Quality of Life Index (SQLI). RESULTS: A subgroup of 106 eligible breast cancer patients with baseline SQLI were randomized into this study and represent the target population discussed in this report. Treatment, age, and SQLI were significant predictors of survival. The addition of efaproxiral to WBRT reduced the death rate by 46% (P = 0.0086). Quality of life was improved in the WBRT + efaproxiral arm compared with the WBRT alone arm (P = 0.019). Quality-adjusted survival was statistically significantly improved by the addition of efaproxiral to WBRT (P = 0.001). CONCLUSION:
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Authors | Charles Scott, John Suh, Baldassarre Stea, Abdenour Nabid, John Hackman |
Journal | American journal of clinical oncology
(Am J Clin Oncol)
Vol. 30
Issue 6
Pg. 580-7
(Dec 2007)
ISSN: 1537-453X [Electronic] United States |
PMID | 18091051
(Publication Type: Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Aniline Compounds
- Propionates
- Radiation-Sensitizing Agents
- efaproxiral
- Oxygen
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Topics |
- Aged
- Aniline Compounds
(therapeutic use)
- Brain Neoplasms
(drug therapy, radiotherapy, secondary)
- Breast Neoplasms
(mortality, pathology)
- Cranial Irradiation
- Female
- Humans
- Middle Aged
- Oxygen
(administration & dosage)
- Propionates
(therapeutic use)
- Quality of Life
- Quality-Adjusted Life Years
- Radiation Dosage
- Radiation-Sensitizing Agents
(therapeutic use)
- Survival Rate
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