Persistent hiccups during rehabilitation hospitalization: three case reports and review of the literature.

Abstract	Persistent hiccups have been reported to occur occasionally during rehabilitation hospitalizations. Hiccups can interfere with patient participation and progress, and this can lengthen and complicate the rehabilitation hospitalization. Chlorpromazine, the only Food and Drug Administration-approved agent specifically indicated for hiccups, is often chosen as a first-line treatment. However, chlorpromazine does not always provide favorable results. The intent of this paper is to (1) review hiccups and implications of persistent hiccups in the rehabilitation setting, (2) provide additional evidence that chlorpromazine is often not the best treatment choice for hiccups in rehabilitative patients, (3) report the effectiveness and favorable tolerability of modest doses of gabapentin in a small case series of three patients, and (4) review potentially effective treatment approaches for hiccups.
Authors	John A Schuchmann, Barry A Browne
Journal	American journal of physical medicine & rehabilitation (Am J Phys Med Rehabil) Vol. 86 Issue 12 Pg. 1013-8 (Dec 2007) ISSN: 0894-9115 [Print] United States
PMID	18090442 (Publication Type: Case Reports, Journal Article, Review)
Chemical References	Amines Anti-Anxiety Agents Anticonvulsants Cyclohexanecarboxylic Acids Dopamine Agonists gamma-Aminobutyric Acid Gabapentin Chlorpromazine
Topics	Aged Amines (administration & dosage, therapeutic use) Anti-Anxiety Agents (administration & dosage, therapeutic use) Anticonvulsants (administration & dosage, therapeutic use) Cerebral Infarction (complications) Chlorpromazine (therapeutic use) Chronic Disease Contraindications Cyclohexanecarboxylic Acids (administration & dosage, therapeutic use) Diabetes Mellitus, Type 2 (complications) Dopamine Agonists (therapeutic use) Female Gabapentin Hemorrhage (complications) Hiccup (diagnosis, drug therapy, etiology) Humans Length of Stay Male Middle Aged Rehabilitation Centers Risk Factors Time Factors gamma-Aminobutyric Acid (administration & dosage, therapeutic use)

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