Abstract |
To evaluate the prognostic value of lactate dehydrogenase (LDH) and beta2-microglobulin (beta2-MG) in chronic lymphocytic leukemia (CLL), a total of 141 cases of CLL had been investigated retrospectively. The Kaplan-Meier method was used to estimate the overall and failure-free survival distributions. Cox regression was used in univariate and multivariate analysis of potential predictors for overall survival. In multivariate analysis, the expression levels of LDH and beta2-MG were divided into 3 groups: (1) elevation of both LDH and beta2-MG levels; (2) elevation of LDH or beta2-MG levels alone; (3) normal levels of both LDH and beta2-MG. The results showed that serum LDH and beta2-MG levels of patients in Binet C were significantly higher than those in Binet A (p=0.034 and p=0.035). The level of serum beta2-MG was not correlated with lymphocyte count (p=0.756). Binet C and high LDH level were associated with significantly shorter overall survival. beta2-MG was not proved to have any association with overall survival. The overall survival time in group of elevation of both LDH and beta2-MG levels was shorter than that in group of normal levels of both LDH and beta2-MG. It is concluded that serum LDH level and Binet stage are important prognostic factors for CLL.
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Authors | Qiu-Dan Shen, Wei Xu, Hui Yu, Li Li, Su-Jiang Zhang, Jian-Yong Li |
Journal | Zhongguo shi yan xue ye xue za zhi
(Zhongguo Shi Yan Xue Ye Xue Za Zhi)
Vol. 15
Issue 6
Pg. 1305-8
(Dec 2007)
ISSN: 1009-2137 [Print] China |
PMID | 18088490
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- beta 2-Microglobulin
- L-Lactate Dehydrogenase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Female
- Humans
- L-Lactate Dehydrogenase
(blood)
- Leukemia, Lymphocytic, Chronic, B-Cell
(blood, diagnosis)
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
- beta 2-Microglobulin
(blood)
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