| Abstract | BACKGROUND: Few exercise trials in cancer patients have reported longer-term follow-up. Here, we report a 6-month follow-up of exercise behavior and patient-rated outcomes from an exercise trial in breast cancer patients. METHODS: Breast cancer patients initiating adjuvant chemotherapy (n = 242) were randomly assigned to usual care (n = 82), resistance exercise training (RET; n = 82), or aerobic exercise training (AET; n = 78) for the duration of their chemotherapy. At 6-month follow-up, participants were mailed a questionnaire that assessed quality of life, self-esteem, fatigue, anxiety, depression, and exercise behavior. RESULTS: Two hundred one (83.1%) participants provided 6-month follow-up data. Adjusted linear mixed-model analyses showed that, at 6-month follow-up, the RET group reported higher self-esteem [adjusted mean difference, 1.6; 95% confidence interval (95% CI), 0.1-3.2; P = 0.032] and the AET group reported lower anxiety (adjusted mean difference, -4.7; 95% CI, -0.0 to -9.3; P = 0.049) compared with the usual care group. Moreover, compared with participants reporting no regular exercise during the follow-up period, those reporting regular aerobic and resistance exercise also reported better patient-rated outcomes, including quality of life (adjusted mean difference, 9.5; 95% CI, 1.2-17.8; P = 0.025). CONCLUSIONS: Improvements in self-esteem observed with RET during breast cancer chemotherapy were maintained at 6-month follow-up whereas reductions in anxiety not observed with AET during breast cancer chemotherapy emerged at 6-month follow-up. Moreover, adopting a combined aerobic and resistance exercise program after breast cancer chemotherapy was associated with further improvements in patient-rated outcomes. Exercise training during breast cancer chemotherapy may result in some longer-term and late effects for selected patient-rated outcomes. |
| Authors | Kerry S Courneya, Roanne J Segal, Karen Gelmon, Robert D Reid, John R Mackey, Christine M Friedenreich, Caroline Proulx, Kirstin Lane, Aliya B Ladha, Jeffrey K Vallance, Qi Liu, Yutaka Yasui, Donald C McKenzie
(Affiliation: University of Alberta, Edmonton, Alberta, Canada. kerry.courneya at ualberta.ca)
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| Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 16
Issue 12
Pg. 2572-8
(Dec 2007)
ISSN: 1055-9965 United States |
| PMID | 18086760
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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| Chemical References |
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| Topics |
- Antineoplastic Agents
(therapeutic use)
- Anxiety
(prevention & control)
- Breast Neoplasms
(therapy)
- Chemotherapy, Adjuvant
- Depression
(prevention & control)
- Exercise Therapy
(methods)
- Fatigue
(prevention & control)
- Female
- Follow-Up Studies
- Humans
- Patient Satisfaction
- Quality of Life
(psychology)
- Self Concept
- Treatment Outcome
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