| Abstract | Many patients with advanced Parkinson's disease (PD) experience motor complications, which negatively impact quality of life, despite optimized oral therapy. It is important for patients to have a treatment option that may provide rapid relief from "off" episodes. In three pivotal, randomized, placebo-controlled trials, subcutaneous apomorphine was effective in acutely treating "off" episodes, significantly improving Unified Parkinson Disease Rating Scale motor scores and reducing the number of "off" hours per day, with a significantly shorter time to patient-declared onset of relief than placebo. Thus, clinical trial data support the efficacy of intermittent subcutaneous apomorphine as a rapid acute treatment for "off" episodes in advanced PD. |
| Authors | Mark Stacy, Dee Silver
(Affiliation: Division of Neurology, Duke University, 932 Morreene Road, MS 3333, Durham, NC27705, USA. mark.stacy at duke.edu <mark.stacy at duke.edu>)
|
| Journal | Parkinsonism & related disorders
(Parkinsonism Relat Disord)
Vol. 14
Issue 2
Pg. 85-92
( 2008)
ISSN: 1353-8020 England |
| PMID | 18083605
(Publication Type: Journal Article, Review)
|
| Chemical References |
- Antiparkinson Agents
- Apomorphine
|
| Topics |
- Antiparkinson Agents
(administration & dosage, adverse effects, therapeutic use)
- Apomorphine
(administration & dosage, adverse effects, therapeutic use)
- Humans
- Injections, Subcutaneous
- Parkinson Disease
(drug therapy, psychology)
- Quality of Life
- Randomized Controlled Trials as Topic
- Registries
|
