Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes.

Abstract

OBJECTIVE:

Resistin, secreted from adipocytes, causes insulin resistance in rodents. We reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at -420 increases type 2 diabetes (T2DM) susceptibility by enhancing promoter activity. We also showed that serum resistin was positively correlated with G at SNP-420, the duration of T2DM, and HbA1c in T2DM. The aim of this study was to determine the relation between serum resistin and factors related to the metabolic syndrome (MetS) in T2DM.

DESIGN, PATIENTS AND MEASUREMENTS:

We analysed 238 Japanese T2DM subjects (124 males and 114 females, age 60.2 +/- 11.3 years, body mass index (BMI) 24.1 +/- 3.9) whose overnight fasting sera were available. Serum resistin was measured using ELISA.

RESULTS:

Serum resistin was higher in subjects with either obesity (P = 0.041), low HDL (P = 0.004), high triglycerides (TG) (P = 0.019), hypertension (HT) (P = 0.001) or atherosclerosis (P = 0.012). Simple regression analysis revealed that serum resistin was correlated with lower HDL, TG and high-sensitivity C-reactive protein (hsCRP). Multiple regression analysis (or logistic regression analysis for HT), adjusted for age, gender, BMI and the duration of T2DM, revealed that serum resistin was correlated with lower HDL (P = 0.008), TG (P = 0.041), HT (P = 0.031) and hsCRP (P = 0.004). Serum resistin was positively correlated with the number of MetS factors, independent of age, gender and the duration of T2DM (P < 0.001). Adjustment by either thiazolidinedione (TZD) treatment or hsCRP had no effects on these findings.

CONCLUSIONS:

Serum resistin was positively correlated with the accumulation of MetS factors in T2DM.

• Authors: Haruhiko Osawa, Masaaki Ochi, Yasuharu Tabara, Kenichi Kato, Junko Yamauchi, Yasunori Takata, Wataru Nishida, Hiroshi Onuma, Ikki Shimizu, Yasuhisa Fujii, Tetsuro Miki, Jun Ohashi, Hideichi Makino
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 69 Issue 1 Pg. 74-80 (Jul 2008) ISSN: 1365-2265 [Electronic] England
• PMID: 18081734 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lipids
• RETN protein, human
• Resistin

Topics

• Aged
• Atherosclerosis (blood, complications)
• Diabetes Mellitus, Type 2 (blood, complications)
• Disease Susceptibility (blood)
• Female
• Humans
• Lipids (blood)
• Male
• Metabolic Syndrome (blood, complications, etiology)
• Middle Aged
• Obesity (blood, complications)
• Resistin (blood)
• Risk Factors