The effects of dipivalyl epinephrine on the eye.

Abstract

We treated one eye each of ten patients with ocular hypertension with dipivalyl epinephrine (DPE), a congener of epinephrine. Pupil size and intraocular pressure were measured before and at intervals up to 240 minutes after instillation of a single drop of DPE in concentrations from 0.005 to 0.5%. Concentrations of 0.025% DPE and greater significantly reduced IOP, and mydriasis was induced by concentrations of 0.1% DPE or greater. Comcentrations of 0.1% DPE, instilled twice daily for one month, significantly reduced intraocular pressure during diurnal testing on days 2 and 31. No toxic side effects were noted. The DPE produced dose-related increases of cyclic adenosine monophosphate in the aqueous humor of rabbits.

• Authors: M B Kaback, S M Podos, T S Harbin Jr, A Mandell, B Becker
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 81 Issue 6 Pg. 768-72 (Jun 1976) ISSN: 0002-9394 [Print] United States
• PMID: 180809 (Publication Type: Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cyclic AMP
• Epinephrine

Topics

• Animals
• Aqueous Humor (analysis)
• Clinical Trials as Topic
• Cyclic AMP (analysis)
• Dose-Response Relationship, Drug
• Epinephrine (analogs & derivatives, pharmacology)
• Hemodynamics (drug effects)
• Humans
• Intraocular Pressure (drug effects)
• Pupil (drug effects)
• Rabbits
• Tonometry, Ocular