| Abstract | We treated one eye each of ten patients with ocular hypertension with dipivalyl epinephrine (DPE), a congener of epinephrine. Pupil size and intraocular pressure were measured before and at intervals up to 240 minutes after instillation of a single drop of DPE in concentrations from 0.005 to 0.5%. Concentrations of 0.025% DPE and greater significantly reduced IOP, and mydriasis was induced by concentrations of 0.1% DPE or greater. Comcentrations of 0.1% DPE, instilled twice daily for one month, significantly reduced intraocular pressure during diurnal testing on days 2 and 31. No toxic side effects were noted. The DPE produced dose-related increases of cyclic adenosine monophosphate in the aqueous humor of rabbits. |
| Authors | M B Kaback, S M Podos, T S Harbin Jr, A Mandell, B Becker |
| Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 81
Issue 6
Pg. 768-72
(Jun 1976)
ISSN: 0002-9394 UNITED STATES |
| PMID | 180809
(Publication Type: Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
| Chemical References |
|
| Topics |
- Animals
- Aqueous Humor
(analysis)
- Clinical Trials as Topic
- Cyclic AMP
(analysis)
- Dose-Response Relationship, Drug
- Epinephrine
(analogs & derivatives, pharmacology)
- Hemodynamics
(drug effects)
- Humans
- Intraocular Pressure
(drug effects)
- Pupil
(drug effects)
- Rabbits
- Tonometry, Ocular
|
