Abstract | BACKGROUND: METHODS: Biopsies were reviewed from 43 patients attending Ain Shams University Hospital (Egypt) who were diagnosed with FMF and treated with colchicine. One-hundred and twelve GI biopsies, obtained over a 14-year period, were reviewed. This included biopsies from stomach body (38), stomach antrum (50), and colon (24). In addition, gastric biopsies were reviewed from 17 control patients who did not have FMF and were not on colchicine. RESULTS: Three patients known to have FMF and on colchicine therapy showed typical histological features of colchicine (metaphase mitoses, epithelial pseudoproliferation, mucin depletion, and frequent apoptosis). These features were seen only in gastric antral biopsies and not in colonic biopsies. None of the control group showed the characteristic morphological features of colchicine toxicity. CONCLUSION: This is the first report of histological changes seen in the stomach following colchicine therapy. In contrast with previous reports, we did not find any definitive change in the large intestine. Our data show that gastric changes can be encountered in symptomatic patients who have recently had colchicine. If these finding are seen histologically, they merit correlation with the clinical impression and should not be interpreted as toxicity in isolation.
|
Authors | Wael Ismail Al-Daraji, Riham M W Al-Mahmoud, Mohammed Ilyas |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 53
Issue 8
Pg. 2079-82
(Aug 2008)
ISSN: 0163-2116 [Print] United States |
PMID | 18080195
(Publication Type: Journal Article, Retracted Publication)
|
Chemical References |
|
Topics |
- Adolescent
- Adult
- Apoptosis
(drug effects)
- Colchicine
(adverse effects)
- Colon
(drug effects)
- Egypt
- Familial Mediterranean Fever
(drug therapy)
- Female
- Gastric Mucosa
(drug effects)
- Humans
- Male
- Middle Aged
- Mitosis
(drug effects)
- Stomach
(drug effects, pathology)
|