Biological effect of mono- and dinuclear alkylamine platinum(II) compounds on human lymphoma cells.

Abstract

The effects of the mononuclear chloro[meso-1,2-bis(4-fluorophenyl)ethylenediamine][hexylamine]platinum(II) chloride HACl and the dinuclear di[meso-1,2-bis(4-fluorophenyl)ethylenediamine]dichloro(mu-1,n-diaminoalkane-N:N')diplatinum(II)dichloride complexes DAHCl (alkane:hexane), DANCl (alkane:nonane) and DADCl (alkane:dodecane) with different alkyl chain length (n) were investigated on non-Hodgkin's lymphoma (NHL) and chronic myeloid leukemia (CML) cell lines. All compounds showed an antiproliferative effect on the NHL cell lines RAJI and U-937 accompanied in the case of DANCl, DAHCl, HACl and cisplatin by an increase in apoptosis. The growth of another NHL (JEKO-1) and one CML cell line (K-562) was decreased only by cisplatin. In contrast to HACl, DAHCl, DANCl and cisplatin, DADCl induced necrosis, suggesting toxicity because cell viability decreased. Similar effects were observed when bone marrow-derived lymphoma cells from a patient with high-grade B-NHL were incubated with the platinum complexes.

• Authors: Timo Kapp, Magnus Krueger, Ingo Ott, Stefanie Steiner, Petra Schumacher, David Nachbaur, Günther Gastl, Ronald Gust, Brigitte Kircher
• Journal: Journal of inorganic biochemistry (J Inorg Biochem) Vol. 102 Issue 4 Pg. 713-20 (Apr 2008) ISSN: 0162-0134 [Print] United States
• PMID: 18078673 (Publication Type: Journal Article)

Chemical References

• Platinum Compounds

Topics

• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Drug Screening Assays, Antitumor
• Humans
• Lymphoma (pathology)
• Platinum Compounds (pharmacology)