| Abstract | Tuberculosis remains to be one of the most important infectious diseases worldwide. Among the estimated 9 million new cases that are anually recorded, antibiotic drug resistance of Mycobacterium tuberculosis has become an increasing problem. Cases of multidrug resistance (MDR), by definition resistance against at least isoniazid and rifampin, are reported worldwide. Moreover, cases of extensively drug-resistant tuberculosis (XDR-TB) with additional resistance to fluoroquinolones and aminoglycosides are also emerging. Patients who are infected with MDR-TB strains need a carefully selected antibiotic combination therapy consisting of four to six alternative drugs according to the results of in vitro drug susceptibility testing. The duration of treatment against MDR-TB is cost-intensive, and is generally recommended for 18 months beyond the first time of sustained culture negativity. Patient adherence to the therapy is essential. As adverse effects of MDR-TB therapy are common, treatment of these patients should be guided by experienced physicians. |
| Authors | Ulf Greinert, Doris Hillemann, Christoph Lange, Elvira Richter
(Affiliation: Klinische Infektiologie, Medizinische Klinik, Forschungszentrum Borstel. ugreinert at fz-borstel.de)
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| Journal | Medizinische Klinik (Munich, Germany : 1983)
(Med Klin (Munich))
Vol. 102
Issue 12
Pg. 957-66
(Dec 15 2007)
ISSN: 0723-5003 Germany |
| Vernacular Title | Antibiotikaresistente Tuberkulose. |
| PMID | 18075716
(Publication Type: Comparative Study, English Abstract, Journal Article, Review)
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| Chemical References |
- Aminoglycosides
- Antitubercular Agents
- Fluoroquinolones
|
| Topics |
- Adult
- Aminoglycosides
(pharmacology)
- Antitubercular Agents
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Drug Resistance, Multiple
(drug effects, genetics)
- Drug Therapy, Combination
- Female
- Fluoroquinolones
(pharmacology)
- Humans
- Male
- Microbial Sensitivity Tests
- Mycobacterium tuberculosis
(drug effects, genetics)
- Patient Compliance
- Patient Selection
- Radiography, Thoracic
- Time Factors
- Tomography, X-Ray Computed
- Tuberculosis, Multidrug-Resistant
(drug therapy, radiography)
|
