| Abstract | OBJECT: Several reports have shown that nonsteroidal antiinflammatory drugs (NSAIDs) have an inhibitory effect in osteogenesis and reduce heterotopic ossification in humans. A deleterious effect of NSAIDs in posterolateral intertransverse process fusion has also been suggested. The authors used a validated rabbit model to try to determine the influence of the NSAID ketoprophen on the fusion rate in lumbar spinal arthrodesis. METHODS: Thirty New Zealand male rabbits underwent posterolateral (intertransverse process) bilateral spinal fusions at a single level, using autologous bone graft obtained from both iliac crests. The animals were randomized after the operation, so that 15 rabbits received ketoprophen as a postoperative analgesic and the other 15 received the postoperative analgesic tramadol. The animals were killed 8 weeks after surgery, and fusion status was determined by inspection, palpation, anteroposterior radiographs, and histological analysis. RESULTS: A solid fusion was obtained in eight rabbits (53%), and pseudarthrosis in seven rabbits (47%) in each group. CONCLUSIONS: These findings suggest that the use of ketoprophen after intertransverse spinal fusion at a single level does not decrease the fusion rate, compared with tramadol. |
| Authors | Julio Urrutia, Rodrigo Mardones, Felipe Quezada
(Affiliation: Department of Orthopaedic Surgery, Pontificia Universidad Catolica de Chile. jurrutia at med.puc.cl)
|
| Journal | Journal of neurosurgery. Spine
(J Neurosurg Spine)
Vol. 7
Issue 6
Pg. 631-6
(Dec 2007)
ISSN: 1547-5654 United States |
| PMID | 18074688
(Publication Type: Comparative Study, Journal Article)
|
| Chemical References |
- Analgesics, Opioid
- Anti-Inflammatory Agents, Non-Steroidal
- Ketoprofen
- Tramadol
|
| Topics |
- Analgesics, Opioid
(adverse effects, pharmacology)
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects, pharmacology)
- Ilium
(transplantation)
- Ketoprofen
(adverse effects, pharmacology)
- Lumbar Vertebrae
(surgery)
- Male
- Postoperative Care
- Pseudarthrosis
(chemically induced)
- Rabbits
- Spinal Fusion
- Tramadol
(adverse effects, pharmacology)
- Wound Healing
(drug effects)
|
