OX40-OX40L interactions: a promising therapeutic target for allergic diseases?

Abstract	Recent advances in understanding the cellular and molecular mechanisms of atopy have shed light on potential targets for the development of new therapies for allergic diseases. In this issue of the JCI, Seshasayee et al. provide direct in vivo evidence that OX40 has critical roles in allergic inflammation mediated by thymic stromal lymphopoietin (TSLP) (see the related article beginning on page 3868). Blockade of interactions between OX40 on Th2 cells and OX40 ligand (OX40L) on TSLP-activated DCs using an OX40L-specific monoclonal antibody, inhibited Th2 cell-mediated immune responses in both mouse and nonhuman primate models of allergic inflammation. The results point to potential therapeutic approaches to targeting the cellular and molecular mechanism underlying TSLP-mediated allergic inflammation.
Authors	Yui-Hsi Wang, Yong-Jun Liu
Journal	The Journal of clinical investigation (J Clin Invest) Vol. 117 Issue 12 Pg. 3655-7 (Dec 2007) ISSN: 0021-9738 [Print] United States
PMID	18074001 (Publication Type: Journal Article, Comment)
Chemical References	Antibodies, Monoclonal Cytokines Membrane Glycoproteins OX40 Ligand Receptors, OX40 TNFRSF4 protein, human TNFSF4 protein, human Tnfrsf4 protein, mouse Tnfsf4 protein, mouse Tumor Necrosis Factor Inhibitors Tumor Necrosis Factors Immunoglobulin E Thymic Stromal Lymphopoietin
Topics	Animals Antibodies, Monoclonal (pharmacology, therapeutic use) Cells, Cultured Cricetinae Cytokines (immunology) Disease Models, Animal Humans Hypersensitivity, Immediate (drug therapy, immunology, pathology) Immunoglobulin E (immunology) Inflammation (drug therapy, genetics, immunology) Lung (immunology, pathology) Macaca mulatta Membrane Glycoproteins (antagonists & inhibitors, immunology) Mice Mice, Inbred BALB C Mice, Transgenic OX40 Ligand (antagonists & inhibitors, immunology) Receptors, OX40 (immunology) Skin (immunology, pathology) Th2 Cells (immunology, pathology) Tumor Necrosis Factor Inhibitors Tumor Necrosis Factors (immunology) Thymic Stromal Lymphopoietin

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