Comparative cytotoxicity of C-1311 in colon cancer in vitro and in vivo using the hollow fiber assay.

Abstract	The aim of this study was to investigate the antiproliferative effects of C-1311 (Symadex), a member of the imidazoacridinone family, in human colorectal cancer cells. In the in vitro screen, C-1311 led to the most prominent growth inhibition in HT29, HCT116, and COLO205 cell lines when compared to oxaliplatin, CPT-11, DFUR, 5-FU and capecitabine. The GI(50)values for C-1311 ranged from 0.12 to 0.83 microM and the TGI concentrations (resulting in total growth inhibition) were 6- to 13-fold lower than those of other agents. In the hollow fiber assay in vivo, C-1311 caused 77% growth inhibition of HT29 in the intraperitoneal site as compared to paclitaxel (17% growth inhibition). In the subcutaneous site, C-1311 produced 57% growth inhibition while paclitaxel showed no cell growth inhibition effects. This unique cytotoxicity profile of C-1311 warrants further investigation and supports its clinical development in colon cancer patients. Symadex (C-1311) is currently in phase 2 clinical trials.
Authors	N Alami, J Paterson, S Belanger, S Juste, C K Grieshaber, B Leyland-Jones
Journal	Journal of chemotherapy (Florence, Italy) (J Chemother) Vol. 19 Issue 5 Pg. 546-53 (Oct 2007) ISSN: 1120-009X [Print] England
PMID	18073154 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Aminoacridines Antineoplastic Agents Organoplatinum Compounds Oxaliplatin Deoxycytidine Capecitabine Irinotecan C 1311 Paclitaxel Fluorouracil Camptothecin
Topics	Aminoacridines (chemistry, pharmacology) Animals Antineoplastic Agents (chemistry, pharmacology) Camptothecin (analogs & derivatives, pharmacology) Capecitabine Cell Line, Tumor Cell Proliferation (drug effects) Clinical Trials, Phase II as Topic Colonic Neoplasms (drug therapy) Deoxycytidine (analogs & derivatives, pharmacology) Drug Screening Assays, Antitumor Fluorouracil (analogs & derivatives, pharmacology) HT29 Cells Humans In Vitro Techniques Irinotecan Mice Mice, Nude Organoplatinum Compounds (pharmacology) Oxaliplatin Paclitaxel (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!