| Abstract | INTRODUCTION: In animal models, lipid emulsion therapy has been shown to ameliorate toxicity from a number of lipid soluble agents. This preliminary study addresses the hypothesis that pretreatment with lipid emulsion protects against propranolol toxicity in rodents. METHODS: Ten spontaneously ventilating Rattus norvegicus rats were pretreated with either lipid emulsion or 0.9% normal saline before undergoing a constant infusion of propranolol until death. An electrocardiogram (ECG) sampling of heart rate and a QRS duration was performed at two-minute intervals until demise. RESULTS: There was no significant difference in lethal doses of propranolol between groups. Comparison of percent change in QRS prolongation and heart rate reduction was performed at 60% of the mean lethal dose in control animals. The percent change in QRS duration was reduced (from -0.9 to 17.3, p=0.016) in the intralipid pretreatment group. Attenuation of propranolol-induced bradycardia observed in the lipid emulsion group approached statistical significance (0% vs. 10.3%, p=0.06). INTERPRETATION: The results suggest that lipid emulsion may be effective in ameliorating propranolol toxicity in rats. Previous work gives reason to postulate a pharmacokinetic mechanism for this effect. The results represent encouraging exploratory work, and further work is planned to evaluate the role of lipid emulsion therapy in propranolol toxicity. |
| Authors | Grant Cave, Martyn G Harvey, Craig D Castle
(Affiliation: Monash Medical Centre, Victoria, Australia. grantcave at xtra.co.nz)
|
| Journal | Journal of medical toxicology : official journal of the American College of Medical Toxicology
(J Med Toxicol)
Vol. 2
Issue 1
Pg. 4-7
(Mar 2006)
ISSN: 1556-9039 United States |
| PMID | 18072104
(Publication Type: Journal Article)
|
| Chemical References |
- Fat Emulsions, Intravenous
- Propranolol
|
| Topics |
- Action Potentials
(drug effects)
- Animals
- Arrhythmias, Cardiac
(chemically induced, physiopathology, prevention & control)
- Disease Models, Animal
- Electrocardiography
- Fat Emulsions, Intravenous
(pharmacology, therapeutic use)
- Female
- Heart Conduction System
(drug effects, physiopathology)
- Heart Rate
(drug effects)
- Propranolol
(poisoning)
- Rats
- Time Factors
|
