| Abstract | In freely moving rats, hippocampus neuronal extracellular calcium concentration (Ca2+)e and seizures were investigated. Application of quinolinic acid 156 nmol (exciting N-methyl-D-aspartate receptor, NMDA) to dorsal hippocampus elicited a decrease in (Ca2+)e by 48 +/- 5% in the infusion area and produced a characteristic abnormal EEG. l-Daurisoline dramatically prevented the reduction in (Ca2+)e, but not seizures (EEG). The results suggest that NMDA-operated calcium channels, but not NMDA-receptors, are involved in the effects of l-daurisoline on Ca2+ influx observed. |
| Authors | Y M Lu, G Q Liu
(Affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing.)
|
| Journal | Zhongguo yao li xue bao = Acta pharmacologica Sinica
(Zhongguo Yao Li Xue Bao)
Vol. 12
Issue 4
Pg. 301-4
(Jul 1991)
ISSN: 0253-9756 CHINA |
| PMID | 1807076
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Alkaloids
- Benzylisoquinolines
- Quinolinic Acids
- daurisoline
- Calcium
|
| Topics |
- Alkaloids
(pharmacology)
- Animals
- Benzylisoquinolines
- Biological Transport, Active
(drug effects)
- Calcium
(metabolism)
- Electroencephalography
(drug effects)
- Hippocampus
(metabolism)
- Male
- Neurons
(metabolism)
- Perfusion
- Quinolinic Acids
- Rats
- Rats, Inbred Strains
- Seizures
(chemically induced, physiopathology)
|
