Effects of l-daurisoline on quinolinic acid-induced Ca2+ influx in hippocampus neurons in freely moving rats.

Abstract

In freely moving rats, hippocampus neuronal extracellular calcium concentration (Ca2+)e and seizures were investigated. Application of quinolinic acid 156 nmol (exciting N-methyl-D-aspartate receptor, NMDA) to dorsal hippocampus elicited a decrease in (Ca2+)e by 48 +/- 5% in the infusion area and produced a characteristic abnormal EEG. l-Daurisoline dramatically prevented the reduction in (Ca2+)e, but not seizures (EEG). The results suggest that NMDA-operated calcium channels, but not NMDA-receptors, are involved in the effects of l-daurisoline on Ca2+ influx observed.

• Authors: Y M Lu, G Q Liu
• Journal: Zhongguo yao li xue bao = Acta pharmacologica Sinica (Zhongguo Yao Li Xue Bao) Vol. 12 Issue 4 Pg. 301-4 (Jul 1991) ISSN: 0253-9756 [Print] China
• PMID: 1807076 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Benzylisoquinolines
• Quinolinic Acids
• daurisoline
• Calcium

Topics

• Alkaloids (pharmacology)
• Animals
• Benzylisoquinolines
• Biological Transport, Active (drug effects)
• Calcium (metabolism)
• Electroencephalography (drug effects)
• Hippocampus (metabolism)
• Male
• Neurons (metabolism)
• Perfusion
• Quinolinic Acids
• Rats
• Rats, Inbred Strains
• Seizures (chemically induced, physiopathology)