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XP-828L in the treatment of mild to moderate psoriasis: randomized, double-blind, placebo-controlled study.

AbstractBACKGROUND:
XP-828L, a protein extract obtained from sweet whey, has demonstrated potential benefit for the treatment of mild to moderate psoriasis in an open-label study.
OBJECTIVE:
To study in a randomized, double-blind, placebo-controlled study the safety and efficacy of XP-828L in the treatment of mild to moderate psoriasis.
DESIGN:
XP-828L 5 g/d (group A, n=42) or placebo (group B, n=42) was given orally for 56 days followed by XP-828L 5 g/d in group A and by XP-828L 10 g/d in group B for an additional 56 days.
RESULTS:
Patients receiving XP-828L 5 g/d for 56 days had an improved Physician's Global Assessment (PGA) score compared with patients under placebo (p less than 0.05). Considering the data of group A only, the PGA score improved from day 1 to day 56 (p less than 0.01); the Psoriasis Area and Severity Index score improved as well, but to a lesser extent (p less than 0.05).
CONCLUSION:
Oral administration of 5 g/d XP-828L compared with a placebo significantly improved the PGA score of patients with mild to moderate psoriasis.
AuthorsYves Poulin, Robert Bissonnette, Christina Juneau, Kim Cantin, Rejean Drouin, Patrice E Poubelle
JournalAlternative medicine review : a journal of clinical therapeutic (Altern Med Rev) Vol. 12 Issue 4 Pg. 352-9 (Dec 2007) ISSN: 1089-5159 [Print] United States
PMID18069904 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Dermatologic Agents
  • Milk Proteins
  • XP-828l
Topics
  • Adult
  • Analysis of Variance
  • Dermatologic Agents (adverse effects, therapeutic use)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Milk Proteins (adverse effects, therapeutic use)
  • Psoriasis (drug therapy, pathology)
  • Quebec
  • Severity of Illness Index

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