[Hyperthermia of male Drosophila melanogaster meiocytes induces abnormalities in both paternal and maternal sex chromosome sets of the offspring].

Abstract

Nondisjunction and loss of sex chromosomes caused by exposure of male Drosophila melanogaster to heat shock (HS) (37 degrees C for 1 h) has been studied to determine the role of mutation l(1)ts403 (sbr10) in the control of chromosome segregation during cell division. Hyperthermia of males at the pupal stage has been demonstrated to increase the number of offspring with abnormalities of not only paternal, but also maternal sex chromosome sets. According to the criterion used, there is a temperature-sensitive period of spermatogenesis, which presumably coincides with meiosis. Phenotypes of some individuals correspond to the presence of two sex chromosomes of obtained from the same parent. The frequency of abnormal chromosome sets in the offspring of male carriers of the sbr10 mutation is about two times higher than in the offspring of males without this mutation.

• Authors: A V K'ergaard, L A Mamon
• Journal: Genetika (Genetika) Vol. 43 Issue 10 Pg. 1379-87 (Oct 2007) ISSN: 0016-6758 [Print] Russia (Federation)
• PMID: 18069342 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drosophila Proteins
• Nuclear Proteins
• RNA-Binding Proteins
• SBR protein, Drosophila

Topics

• Animals
• Chromosome Aberrations
• Chromosome Segregation (genetics)
• Drosophila Proteins (genetics, physiology)
• Drosophila melanogaster (genetics)
• Hot Temperature
• Male
• Meiosis
• Mutation
• Nuclear Proteins (genetics, physiology)
• RNA-Binding Proteins (genetics, physiology)
• Spermatogenesis
• X Chromosome (genetics)
• Y Chromosome (genetics)