Abstract | BACKGROUND: METHODS: Whole-body images were acquired at various times after administration of (188)Re-anti-CD20, obtained from instant freeze-dried kit formulations with radiochemical purity >95%. Regions of interest (ROIs) were drawn around source organs in each time frame. The cpm of each ROI was converted to activity using the conjugate view counting method. The image sequence was used to extrapolate time-activity curves in each organ to calculate the total number of disintegrations (N) that occurred in the source regions. N data were the input for the OLINDA/EXM code to calculate internal radiation dose estimates. RESULTS: Dosimetric studies indicated that after administration of 4.87-8.72 GBq of (188)Re-anti-CD20, the absorbed dose to total body would be 0.75 Gy, which corresponds with the recommended dose for NHL therapies. CONCLUSIONS:
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Authors | Eugenio Torres-García, Guillermina Ferro-Flores, Consuelo Arteaga de Murphy, Luis Correa-González, Pablo A Pichardo-Romero |
Journal | Archives of medical research
(Arch Med Res)
Vol. 39
Issue 1
Pg. 100-9
(Jan 2008)
ISSN: 0188-4409 [Print] United States |
PMID | 18068002
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 188Re-anti-CD20 monoclonal antibody
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Rituximab
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Topics |
- Adolescent
- Aged
- Antibodies, Monoclonal
(pharmacokinetics, therapeutic use)
- Antibodies, Monoclonal, Murine-Derived
- Female
- Humans
- Lymphoma, Non-Hodgkin
(radiotherapy)
- Male
- Middle Aged
- Radioimmunotherapy
- Rituximab
- Whole Body Imaging
- Whole-Body Counting
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