[Association of thiazide-sensitive Na+-Cl* cotransporter gene polymorphisms with the risk of essential hypertension].

Abstract

OBJECTIVE:

To investigate the association of thiazide-sensitive Na+ -Cl* cotransporter (TSC) gene 1784C/T and 2736G/A polymorphisms with the risk of essential hypertension (EH) in a Han nationality population.

METHODS:

A community-based, case-control study including 190 EH patients and 94 sex- and age-matched controls was conducted. Genotypes of TSC gene 1784C/T and 2736G/A polymorphisms were analyzed by gene chip technology.

RESULTS:

The genotype (1784C/T CC, CT, TT:87, 88, 15 vs 36, 52, 6û2736G/A GG, AG, AA:167, 22, 1 vs 83, 10, 1) and alleles frequency (1784C/T C, T:68.9%, 31.1% vs 66.0%, 34.0%; 2736G/A G,A:93.7%, 6.3% vs 93.6%, 6.4%) distribution of 1784C/T and 2736G/A showed no significant difference between the EH group and the control group (P >0.05). Moreover, no significant difference was observed in the frequencies distribution of four haplotypes (P > 0.05); Logistic regression analysis of haplotypes showed that the risk of EH had no significant difference in the population with different haplotypes (P > 0.05).

CONCLUSION:

The 1784C/T and 2736G/A polymorphisms of TSC gene may not play an important role in the etiology of EH in a Han nationality population. The studies in the future are warranted to validate our findings.

• Authors: Yi-yang Zhan, Xiao Jiang, Gang Lin, Jian Li, Hai-hui Sheng, Hua-sheng Xiao, Yun-lin Cheng, Jun Huang
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 24 Issue 6 Pg. 703-5 (Dec 2007) ISSN: 1003-9406 [Print] China
• PMID: 18067089 (Publication Type: English Abstract, Journal Article)

Chemical References

• Receptors, Drug
• Sodium Chloride Symporters
• thiazide receptor

Topics

• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Haplotypes
• Humans
• Hypertension (epidemiology, genetics)
• Male
• Middle Aged
• Polymorphism, Genetic
• Polymorphism, Single Nucleotide
• Receptors, Drug (genetics)
• Risk
• Sodium Chloride Symporters (genetics)