| Abstract | Multiple myeloma (MM) patients have a propensity for thromboembolic events (TE), and treatment with thalidomide/dexamethasone or lenalidomide/dexamethasone increases this risk. This report describes the use of low-dose aspirin (81 mg) as primary thromboprophylaxis in three series of MM patients receiving thalidomide or lenalidomide with other drugs. In the first regimen (clarithromycin, thalidomide, dexamethasone), initiation of low-dose aspirin negated the occurrence of any further TE. In a second study, prophylactic aspirin given with thalidomide/dexamethasone resulted in a rate of TE similar to that seen with dexamethasone alone (without aspirin). A third study (n = 72) evaluated thrombosis rates with aspirin and a lenalidomide-containing regimen (clarithromycin, lenalidomide, dexamethasone). Of nine occurrences of thromboembolism, five were associated with aspirin interruption or poor compliance. Low-dose aspirin appears to reduce the incidence of thrombosis with these regimens. Routine use of aspirin as antithrombotic prophylaxis in MM patients receiving immunomodulatory drugs with corticosteroids is warranted. |
| Authors | Ruben Niesvizky, Déborah Martínez-Baños, Jessica Jalbrzikowski, Paul Christos, Jessica Furst, Maria De Sancho, Tomer Mark, Roger Pearse, Madhu Mazumdar, Faiza Zafar, Karen Pekle, John Leonard, David Jayabalan, Morton Coleman
(Affiliation: Center of Excellence for Lymphoma and Myeloma, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA. run9001 at med.cornell.edu)
|
| Journal | Leukemia & lymphoma
(Leuk Lymphoma)
Vol. 48
Issue 12
Pg. 2330-7
(Dec 2007)
ISSN: 1042-8194 England |
| PMID | 18067007
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antineoplastic Agents
- Heparin, Low-Molecular-Weight
- lenalidomide
- Thalidomide
- Aspirin
|
| Topics |
- Adult
- Aged
- Antineoplastic Agents
(adverse effects)
- Aspirin
(therapeutic use)
- Drug Therapy, Combination
- Female
- Heparin, Low-Molecular-Weight
(therapeutic use)
- Humans
- Male
- Middle Aged
- Multiple Myeloma
(drug therapy)
- Retrospective Studies
- Thalidomide
(administration & dosage, adverse effects, analogs & derivatives)
- Thrombosis
(prevention & control)
|
