Development of an antitumor adenosine analog, 3''-ethynyladenosine.

Abstract

3'-ethynyladenosine (EAdo) was an adenosine analog with potent antitumor activity against various human tumor cells in vitro. However, EAdo was enzymatically inactivated by adenosine deaminase (ADA) in vitro and in vivo. Therefore, we synthesized two ADA-resistant EAdo derivatives (2-F-EAdo and EAdo-5'-monophosphate, EAMP) and examined their antitumor activities.

• Authors: Yoshio Endo, Tohru Obata, Makoto Nomura, Masakazu Fukushima, Yuji Yamada, Akira Matsuda, Takuma Sasaki
• Journal: Nucleosides, nucleotides & nucleic acids (Nucleosides Nucleotides Nucleic Acids) Vol. 26 Issue 6-7 Pg. 691-4 ( 2007) ISSN: 1525-7770 [Print] United States
• PMID: 18066881 (Publication Type: Journal Article)

Chemical References

• 3'-ethynyladenosine
• Antineoplastic Agents
• Adenosine Deaminase
• Adenosine

Topics

• Adenosine (analogs & derivatives, chemical synthesis, chemistry, pharmacology)
• Adenosine Deaminase (metabolism)
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Deamination (drug effects)
• Drug Resistance, Neoplasm (drug effects)
• Drug Screening Assays, Antitumor
• Humans