Participation of hippocampal ionotropic glutamate receptors in histamine H(1) antagonist-induced memory deficit in rats.

Pyrilamine, a selective histamine H(1) antagonist, impaired spatial memory, and decreased hippocampal theta activity during a radial maze task.
We investigated the ameliorative effects of glutamatergic drugs on pyrilamine-induced spatial memory deficit and the decrease in hippocampal theta activity in rats.
Drug effects were measured using an eight-arm radial maze with four arms baited. Hippocampal theta rhythm during the radial maze task was also recorded with a polygraph system using a telemetric technique.
Intraperitoneal injection of pyrilamine (35 mg/kg) resulted in impaired reference and working memory in the radial maze task and a decrease in the amplitude and power of hippocampal theta waves. The working memory deficit and the decrease in hippocampal theta power were antagonized by intrahippocampal injection of D: -cycloserine (1 microg/side), spermidine (10 microg/side), spermine (10 microg/side), aniracetam (1 microg/side), and 1-(1,3-benzodioxol-5-ylcarbonyl) piperidine (1-BCP) (1 microg/side), but not concanavalin A.
These results clearly indicate that H(1) antagonist-induced working memory deficit, and the decrease in hippocampal theta activity was closely associated with hippocampal glutamatergic neurotransmission mediated by N-methyl-D: -aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
AuthorsTakayoshi Masuoka, Shunsuke Saito, Chiaki Kamei
JournalPsychopharmacology (Psychopharmacology (Berl)) Vol. 197 Issue 1 Pg. 107-14 (Mar 2008) ISSN: 0033-3158 [Print] Germany
PMID18066536 (Publication Type: Journal Article)
Chemical References
  • Dioxoles
  • Gluk2 kainate receptor
  • Histamine H1 Antagonists
  • Piperidines
  • Pyrrolidinones
  • Receptors, AMPA
  • Receptors, Histamine H1
  • Receptors, Kainic Acid
  • Receptors, N-Methyl-D-Aspartate
  • Concanavalin A
  • Spermine
  • 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine
  • aniracetam
  • Cycloserine
  • Pyrilamine
  • Spermidine
  • Animals
  • Concanavalin A (pharmacology)
  • Cycloserine (pharmacology)
  • Dioxoles (pharmacology)
  • Dose-Response Relationship, Drug
  • Electroencephalography (drug effects)
  • Fourier Analysis
  • Hippocampus (drug effects)
  • Histamine H1 Antagonists (pharmacology)
  • Injections
  • Male
  • Maze Learning (drug effects)
  • Mental Recall (drug effects)
  • Orientation (drug effects)
  • Piperidines (pharmacology)
  • Pyrilamine (antagonists & inhibitors, pharmacology)
  • Pyrrolidinones (pharmacology)
  • Rats
  • Rats, Wistar
  • Receptors, AMPA (drug effects)
  • Receptors, Histamine H1 (drug effects)
  • Receptors, Kainic Acid (drug effects)
  • Receptors, N-Methyl-D-Aspartate (drug effects)
  • Signal Processing, Computer-Assisted
  • Spermidine (pharmacology)
  • Spermine (pharmacology)
  • Theta Rhythm

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