Glioblastoma multiforme: the role of DSB repair between genotype and phenotype.

Abstract

Glioblastoma is the most frequent primary brain tumor in adults. The average survival time of less than 1 year did not improve notably over the last three decades. The dismal prognosis of glioblastoma patients is largely due to the striking radioresistance of this tumor. Here, we attempt a combined view on the genetics, the repair mechanisms and the radioresistance of glioblastoma. Specifically, we address the role of DNA-PKcs and the novel potential end-joining factor KUB3 in maintaining the radioresistant phenotype, the interrelationship between genetic lesions and repair mechanisms, and new perspectives that emerge from the identification of glioblastoma stem cells.

• Authors: U Fischer, E Meese
• Journal: Oncogene (Oncogene) Vol. 26 Issue 56 Pg. 7809-15 (Dec 10 2007) ISSN: 1476-5594 [Electronic] England
• PMID: 18066094 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• DNA, Neoplasm

Topics

• Animals
• Brain Neoplasms (genetics)
• DNA Breaks, Double-Stranded
• DNA Repair
• DNA, Neoplasm (genetics)
• Genotype
• Glioblastoma (genetics)
• Humans
• Phenotype