Upper and lower urinary tract infection caused by Klebsiella pneumoniae serotype K2 and CTX-M-15 beta-lactamase-producing serotype K1: a case report and characterization of serum killing resistance.

Abstract

CTX-M-15 beta-lactamase-producing Klebsiella pneumoniae serotype K1 was isolated from a patient with fatal upper urinary tract infection (UTI) complicated by sepsis caused by K. pneumoniae serotype K2. Transfer of a CTX-M-15 beta-lactamase plasmid from the K1 to the K2 strain was observed. However, plasmid acquisition by the K2 strain did not occur in vivo, suggesting that the K1 strain might not have contributed directly to the upper UTI. In addition, effects of K serotypes and plasmid acquisition on K. pneumoniae serum resistance were examined.

• Authors: Noriyuki Nagano, Christophe Cordevant, Yukiko Nagano
• Journal: Journal of medical microbiology (J Med Microbiol) Vol. 57 Issue Pt 1 Pg. 121-124 (Jan 2008) ISSN: 0022-2615 [Print] England
• PMID: 18065678 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• beta-lactamase CTX-M-15
• beta-lactamase K1
• beta-Lactamases

Topics

• Aged
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Blood Bactericidal Activity (immunology)
• Humans
• Klebsiella Infections (mortality, physiopathology)
• Klebsiella pneumoniae (drug effects, enzymology, genetics, isolation & purification)
• Male
• Urinary Tract Infections (microbiology)
• beta-Lactamases (genetics, metabolism)