Abstract | OBJECTIVE: METHODS: We applied SAI in ten CADASIL patients and in ten age-matched normal controls. SAI is a phenomenon observed on motor evoked potential when transcranial magnetic stimulation is delivered after a time ranging from 2 to 8 ms longer than the time needed by the peripheral nerve afferent input to reach the somatosensory cortex. RESULTS: The amount of short latency afferent inhibition was significantly smaller in CADASIL patients than in controls (79.5+/-21.7% Vs 42.7+/-14.1% of test size; p<0.001, two tailed Mann-Whitney test). The mean resting motor threshold (RMT) was significantly lower in CADASIL patients than in controls (49.4+/-14.4% Vs 65.6+/-15.4%; p=0.02). CONCLUSIONS: SIGNIFICANCE:
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Authors | Fiore Manganelli, Michele Ragno, Gabriella Cacchiò, Valeria Iodice, Luigi Trojano, Flavia Silvaggio, Maria Scarcella, Michela Grazioli, Lucio Santoro, Anna Perretti |
Journal | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
(Clin Neurophysiol)
Vol. 119
Issue 2
Pg. 351-5
(Feb 2008)
ISSN: 1388-2457 [Print] Netherlands |
PMID | 18065265
(Publication Type: Journal Article)
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Topics |
- Aged
- CADASIL
(pathology, physiopathology)
- Case-Control Studies
- Electric Stimulation
- Electromyography
(methods)
- Evoked Potentials, Motor
(physiology, radiation effects)
- Evoked Potentials, Somatosensory
(physiology)
- Female
- Humans
- Male
- Middle Aged
- Motor Cortex
(physiopathology)
- Neural Inhibition
(physiology)
- Neuropsychological Tests
- Reaction Time
(physiology)
- Somatosensory Cortex
(physiopathology)
- Statistics, Nonparametric
- Time Factors
- Transcranial Magnetic Stimulation
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