Abstract | OBJECTIVE: METHODS: Quantitative autoradiography was used to investigate the binding densities of [(3)H] SR141716A (a selective antagonist) and [(3)H] CP-55940 (an agonist) to the CB1 receptors in the STG. Post-mortem brain tissue was obtained from the NSW Tissue Resource Centre (Australia). RESULTS: Contrasting to previous findings in the alterations of CB1 receptor densities in the prefrontal, anterior and posterior cingulate cortex of schizophrenia, which were suggested to be associated to impairment of cognition function, no significant difference was found between the schizophrenia and control cases in both [(3)H] SR141716A and [(3)H] CP-55940 binding. CONCLUSION:
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Authors | Chao Deng, Mei Han, Xu-Feng Huang |
Journal | Neuroscience bulletin
(Neurosci Bull)
Vol. 23
Issue 6
Pg. 341-7
(Nov 2007)
ISSN: 1673-7067 [Print] Singapore |
PMID | 18064064
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptor, Cannabinoid, CB1
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Topics |
- Adult
- Aged
- Autoradiography
- Case-Control Studies
- Humans
- Middle Aged
- Receptor, Cannabinoid, CB1
(agonists, antagonists & inhibitors, metabolism)
- Reference Values
- Schizophrenia
(metabolism, physiopathology)
- Temporal Lobe
(metabolism)
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