A synthetic triacylated pseudo-dipeptide molecule promotes Th1/TReg immune responses and enhances tolerance induction via the sublingual route.

Abstract

In this study, we tested two triacylated pseudo-dipeptidic molecules, OM-197-MP-AC and OM-294-BA-MP as candidate adjuvants for allergy vaccines. Both molecules induce human dendritic cell (h-DC) maturation and polarize naïve T cells toward the Th1 type with IFNgamma production. Only OM-294-BA-MP induces IL10 gene expression both in monocyte-derived DCs and CD4+ naïve T cells. Sublingual administration of OM-294-BA-MP plus the antigen enhances tolerance induction in BALB/c mice with established asthma to ovalbumin with an impact on both airways hyperresponsiveness and lung inflammation. Given its Th1/Treg polarizing properties, OM-294-BA-MP is a valid candidate for sublingual allergy vaccines.

• Authors: Laurent Mascarell, Laurence Van Overtvelt, Vincent Lombardi, Alain Razafindratsita, Hélène Moussu, Stéphane Horiot, Henri Chabre, David Limal, Stéphane Moutel, Jacques Bauer, Carlo Chiavaroli, Philippe Moingeon
• Journal: Vaccine (Vaccine) Vol. 26 Issue 1 Pg. 108-18 (Dec 21 2007) ISSN: 0264-410X [Print] Netherlands
• PMID: 18063445 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Dipeptides
• Interferon-gamma

Topics

• Adjuvants, Immunologic (pharmacology)
• Administration, Sublingual
• Animals
• CD4-Positive T-Lymphocytes (drug effects, physiology)
• Cell Polarity
• Dendritic Cells (drug effects, physiology)
• Desensitization, Immunologic (methods)
• Dipeptides (pharmacology)
• Female
• Humans
• Immune Tolerance
• Interferon-gamma (biosynthesis)
• Mice
• Mice, Inbred BALB C
• T-Lymphocytes, Regulatory (immunology)
• Th1 Cells (immunology)