| Abstract | History of angioedema is a contraindication for ACE-inhibitors. Angioedema is caused by: 1. a decreased degradation of bradykinin, 2. a defect in C 1-esterase-inhibitor with the increased generation of bradykinin or 3. other trigger mechanisms as food, pollen and stress. AT1 receptor antagonists do not inhibit the degradation of bradykinin. Thus angioedema is no contraindication for AT1 receptor antagonists. In patients with an anamnestic angioedema or ACE-induced angioedema AT1 receptor antagonists can be given under close monitoring provided that there is strong indication for inhibition of the renin-angiotensin system. |
| Authors | Gesine Picksak, Dirk O Stichtenoth
(Affiliation: Institut für Klinische Pharmakologie, Medizinische Hochschule Hannover, Hannover. Picksak.Gesine at mh-hannover.de)
|
| Journal | Medizinische Monatsschrift für Pharmazeuten
(Med Monatsschr Pharm)
Vol. 30
Issue 11
Pg. 415-7
(Nov 2007)
ISSN: 0342-9601 Germany |
| Vernacular Title | Angiotensin-II-Antagonisten alternativ zu ACE-Hemmern bei Angioödem? |
| PMID | 18062333
(Publication Type: English Abstract, Journal Article, Review)
|
| Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Angiotensin-Converting Enzyme Inhibitors
|
| Topics |
- Angioedema
(drug therapy)
- Angiotensin II Type 1 Receptor Blockers
(therapeutic use)
- Angiotensin-Converting Enzyme Inhibitors
(contraindications, therapeutic use)
- Humans
|
