Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: In odontogenic epithelium, a similar expression of RANK, RANKL, and OPG was observed in all samples. With regard to stroma, the number of RANK-positive and RANKL-positive cells was higher in solid/multicystic ameloblastomas compared with dentigerous cysts. Dental follicles had lower numbers of RANK-positive, RANKL-positive, and OPG-positive cells than solid/multicystic ameloblastomas and keratocystic odontogenic tumors. The majority of solid/multicystic ameloblastomas (75%) and unicystic ameloblastomas (62.5%) had higher numbers of RANKL-positive than OPG-positive cells. In contrast, 62.4% of keratocystic odontogenic tumors and 100% of dentigerous cysts exhibited a higher content of OPG-positive than RANKL-positive cells. CONCLUSION: Our results indicate differences in the RANK, RANKL, and OPG expression in odontogenic epithelial tumors. The imbalance of these factors could contribute to the differential bone/ tooth resorption activity in these lesions.
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Authors | Tarcília Aparecida da Silva, Aline Carvalho Batista, Elismauro Francisco Mendonça, Cláudio Rodrigues Leles, Sandra Fukada, Fernando Queiroz Cunha |
Journal | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod)
Vol. 105
Issue 3
Pg. 333-41
(Mar 2008)
ISSN: 1528-395X [Electronic] United States |
PMID | 18061491
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- NF-kappa B
- Osteoprotegerin
- RANK Ligand
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Topics |
- Ameloblastoma
(metabolism, pathology)
- Cell Count
- Dentigerous Cyst
(metabolism, pathology)
- Epithelial Cells
(metabolism)
- Gene Expression
- Humans
- Jaw Neoplasms
(metabolism, pathology)
- NF-kappa B
(biosynthesis)
- Odontogenic Tumors
(metabolism, pathology)
- Osteolysis
(pathology)
- Osteoprotegerin
(biosynthesis)
- RANK Ligand
(biosynthesis)
- Root Resorption
(pathology)
- Statistics, Nonparametric
- Stromal Cells
(metabolism)
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