| Abstract | OBJECTIVE: To assess the recovery effect of panaxatriol (PT) on myeloid hemopoiesis in radiation injured mice, and analyze the underlying mechanism. METHODS: This study was carried out in the Animal Center of Shandong University, Jinan, China, during March to September 2006. Forty-five inbred albino mice were separated randomly into 3 groups: control group, radiation group, and radiation + PT group (200 mg/kg/d, 3 weeks). Peripheral blood cells were detected by globuli meter, CD34+ cells in bone marrow were detected by flow cytometry, and the protein expression of granulocyte-macrophage colony stimulating factor (GM-CSF) was detected by immunocytochemistry. RESULTS: The numbers of peripheral blood cells and bone marrow CD34+ cells, and the expression of GM-CSF in the radiation group were lower than in the control group. After treatment with PT, the numbers of peripheral blood cells and CD34+ cells, and the expression of GM-CSF increased significantly. CONCLUSION: Panaxatriol can relieve myelosuppression induced by radiation injury. The abilities of regulating the expression of hemopoietic growth factor GM-CSF and promoting the maturation of bone marrow cells may be responsible for some of these beneficial effects. |
| Authors | Fen Y Liu, Jun N Wang, Shu D Yu, Bo Wang, Ji D Zhang
(Affiliation: Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China. yuliufenye at 126.com)
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| Journal | Saudi medical journal
(Saudi Med J)
Vol. 28
Issue 12
Pg. 1791-5
(Dec 2007)
ISSN: 0379-5284 Saudi Arabia |
| PMID | 18060204
(Publication Type: Journal Article)
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| Chemical References |
- Ginsenosides
- Hemoglobins
- Triterpenes
- panaxatriol
- Granulocyte-Macrophage Colony-Stimulating Factor
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| Topics |
- Animals
- Blood Cell Count
- Bone Marrow Cells
(metabolism)
- Ginsenosides
(pharmacology)
- Granulocyte-Macrophage Colony-Stimulating Factor
(metabolism)
- Hematopoiesis
(drug effects)
- Hemoglobins
(metabolism)
- Mice
- Radiation Injuries
(blood)
- Triterpenes
(pharmacology)
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