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Distribution of neuronal nitric oxide synthase (nNOS)-immunoreactive elements in the rabbit piriform cortex.

Abstract
The piriform cortex (PC), the primary olfactory cortex, is involved in the processes of learning and stress response and possibly plays an important role in epileptogenic activity. The results of several recent studies suggest that those PC neurons that contain neuronal nitric oxide synthase (nNOS) may play a key role during spatial learning and in the modulation of initiation, propagation and generalisation of seizures in various experimental models and may influence neuronal vulnerability after epileptic insults. The aim of this study was to characterise the pattern of distribution and morphology of nNOS-immunoreactive elements in PC of the adult rabbit. The co-localisation of nNOS and calretinin (CR) was also studied. The pattern of nNOS-ir within the rabbit PC is similar to that described previously in other mammals. The morphology of nNOS-ir elements, namely varicose fibres and Cajal-Retzius cells, suggest that NO has an important influence on PC function. Surprisingly, in the rabbit PC nNOS-ir elements show a very low level of co-localisation with CR-ir.
AuthorsS Wójcik, E Spodnik, J H Spodnik, J Dziewiatkowski, J Moryś
JournalFolia morphologica (Folia Morphol (Warsz)) Vol. 66 Issue 4 Pg. 296-302 (Nov 2007) ISSN: 0015-5659 [Print] Poland
PMID18058751 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Calbindin 2
  • S100 Calcium Binding Protein G
  • Nitric Oxide
  • Nitric Oxide Synthase Type I
Topics
  • Animals
  • Axons (enzymology, ultrastructure)
  • Brain Mapping
  • Calbindin 2
  • Cell Shape (physiology)
  • Epilepsy (enzymology, physiopathology)
  • Immunohistochemistry
  • Learning (physiology)
  • Neural Pathways (cytology, enzymology)
  • Nitrergic Neurons (cytology, enzymology)
  • Nitric Oxide (biosynthesis)
  • Nitric Oxide Synthase Type I (metabolism)
  • Olfactory Pathways (cytology, enzymology)
  • Oxidative Stress (physiology)
  • Parahippocampal Gyrus (cytology, enzymology)
  • Rabbits (anatomy & histology, metabolism)
  • S100 Calcium Binding Protein G (metabolism)
  • Species Specificity
  • Stem Cells (cytology, enzymology)

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