Abstract | RATIONALE: OBJECTIVES: The aim of this study was to elucidate the mechanisms underlying the paradoxical relationship between cannabinoid exposure and sociability. MATERIALS AND METHODS: We investigated the effect of cannabinoid agonists with a different mechanism of action on social play behavior in adolescent rats. In addition, we examined whether endocannabinoid neurotransmission interacts with opioid and dopaminergic neurotransmission in the modulation of social play behavior. RESULTS: CONCLUSIONS:
Cannabinoid neurotransmission can both enhance and inhibit social interaction in adolescent rats depending on how the endocannabinoid system is stimulated. Activation of cannabinoid receptors throughout the brain, which occurs during cannabis use, inhibits sociability. In contrast, on-demand release of endocannabinoids facilitates social interaction, which is magnified by indirect cannabinoid agonists through an interaction with opioid and dopaminergic neurotransmission. These results shed light on the paradoxical relationship between cannabis exposure and sociability and suggest that endocannabinoid degradation inhibitors hold promise for the treatment of social dysfunctions.
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Authors | Viviana Trezza, Louk J M J Vanderschuren |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 197
Issue 2
Pg. 217-27
(Apr 2008)
ISSN: 0033-3158 [Print] Germany |
PMID | 18058088
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Opioid
- Benzamides
- Benzoxazines
- Cannabinoids
- Carbamates
- Dopamine Antagonists
- Morpholines
- Naphthalenes
- Narcotic Antagonists
- Piperidines
- Pyrazoles
- Receptors, Dopamine
- cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester
- Naloxone
- (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone
- Morphine
- Flupenthixol
- Rimonabant
- Dopamine
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Topics |
- Analgesics, Opioid
(pharmacology)
- Animals
- Benzamides
(pharmacology)
- Benzoxazines
(pharmacology)
- Cannabinoids
(pharmacology)
- Carbamates
(pharmacology)
- Dopamine
(physiology)
- Dopamine Antagonists
(pharmacology)
- Exploratory Behavior
(drug effects)
- Flupenthixol
(pharmacology)
- Male
- Morphine
(pharmacology)
- Morpholines
(pharmacology)
- Motor Activity
(drug effects)
- Naloxone
(pharmacology)
- Naphthalenes
(pharmacology)
- Narcotic Antagonists
(pharmacology)
- Piperidines
(pharmacology)
- Play and Playthings
- Pyrazoles
(pharmacology)
- Rats
- Rats, Wistar
- Receptors, Dopamine
(drug effects)
- Reward
- Rimonabant
- Social Behavior
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