2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice.

Abstract

The effect of the serotonin 5-HT(2A/2C)-receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) on Delta(9)-tetrahydrocannabinol (THC)-induced catalepsy-like immobilization was studied in mice. DOI (0.3 and 1 mg/kg, i.p.) significantly inhibited the catalepsy-like immobilization induced by THC (10 mg/kg, i.p.). In contrast, the selective 5-HT(2C)-receptor agonist 8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one (WAY 161503) had no effect on this catalepsy-like immobilization. Moreover, the 5-HT(2A)-receptor antagonist ketanserin (0.3 mg/kg, i.p.) reversed the inhibition of THC-induced catalepsy-like immobilization caused by DOI (1 mg/kg), whereas the selective 5-HT(2C)-receptor antagonist 6-chloro-2,3-dihydro-5-methyl-N-[6-(2-methyl-3-pyridinyl)oxyl]-3-pyridinyl]-1H-indole-1-carboxyamide (SB 242084) did not affect this inhibitory effect of DOI. On the other hand, ketanserin (0.3 and 1 mg/kg, i.p.) enhanced the catalepsy-like immobilization induced by THC (6 mg/kg, i.p.). Thus, on the basis of these results, it appears that 5-HT(2A)-receptor mechanisms might be responsible for the inhibitory effect of DOI on THC-induced catalepsy-like immobilization.

• Authors: Nobuaki Egashira, Emi Koushi, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 105 Issue 4 Pg. 361-6 (Dec 2007) ISSN: 1347-8613 [Print] Japan
• PMID: 18057774 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline
• 8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a)quinoxalin-5(6H)-one
• Aminopyridines
• Amphetamines
• Indoles
• Pyrazines
• Quinoxalines
• Serotonin 5-HT2 Receptor Agonists
• Serotonin Receptor Agonists
• Dronabinol
• Ketanserin
• 4-iodo-2,5-dimethoxyphenylisopropylamine

Topics

• Aminopyridines (administration & dosage, pharmacology)
• Amphetamines (administration & dosage, pharmacology)
• Analysis of Variance
• Animals
• Animals, Outbred Strains
• Behavior, Animal (drug effects)
• Dose-Response Relationship, Drug
• Dronabinol (toxicity)
• Freezing Reaction, Cataleptic (drug effects)
• Indoles (administration & dosage, pharmacology)
• Injections, Intraperitoneal
• Ketanserin (administration & dosage, pharmacology)
• Male
• Mice
• Pyrazines (administration & dosage, pharmacology)
• Quinoxalines (administration & dosage, pharmacology)
• Serotonin 5-HT2 Receptor Agonists
• Serotonin Receptor Agonists (administration & dosage, pharmacology)
• Time Factors