Use of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide (P-15) in the treatment of class II furcation defects: a clinical and radiographic study in humans.

Abstract

BACKGROUND:

This study compared clinical and radiographic findings for the treatment of Class II furcation defects in human mandibular molars using anorganic bovine-derived hydroxyapatite matrix (ABM)/cell-binding peptide (P-15) or open flap debridement (OFD).

METHODS:

Twelve subjects showing two comparable Class II furcation defects in their mandibular molars were enrolled. The defects in each subject were assigned randomly to the test (ABM/P-15) or the control (OFD) group. Clinical measurements and standardized radiographs were taken at baseline and 6 to 7 months after surgery.

RESULTS:

There were no statistically significant differences between the test and control groups for any clinical or radiographic parameter (P >0.05). On comparing the baseline and final measurements, the gain in horizontal clinical attachment level and reduction in gingival recession were significant only in the test group (P < or =0.02), whereas the gain in the vertical clinical attachment level was significant in both groups (P < or =0.04). In the test group, four of 12 sites showed complete closure, and five showed partial closure; in the control group, three defects showed complete closure, and four showed partial closure (P = 0.42). Subtraction radiography revealed similar gains in bone height and increases in mean bone density with both treatments (P >0.05).

CONCLUSIONS:

ABM/P-15 yielded favorable results in the treatment of Class II furcation defects over a 6-month evaluation period; however, there was no difference compared to OFD. Further studies using a larger sample size are needed to confirm the present findings.

• Authors: Ana L Eto, Julio C Joly, Marjorie Jeffcoat, Ney S de Araújo, Vera C de Araújo, Patricia R Cury
• Journal: Journal of periodontology (J Periodontol) Vol. 78 Issue 12 Pg. 2277-83 (Dec 2007) ISSN: 0022-3492 [Print] United States
• PMID: 18052699 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Peptide Fragments
• cell-binding peptide P-15
• Collagen
• Durapatite

Topics

• Adult
• Animals
• Bone Regeneration
• Cattle
• Collagen (therapeutic use)
• Double-Blind Method
• Durapatite (therapeutic use)
• Female
• Furcation Defects (diagnostic imaging, etiology, surgery)
• Humans
• Male
• Middle Aged
• Peptide Fragments (therapeutic use)
• Periodontitis (complications)
• Radiography, Bitewing
• Statistics, Nonparametric
• Subtraction Technique
• Surgical Flaps
• Treatment Outcome