[Effect of ursodeoxycholic acid in an experimental colon cancer model].

Abstract

AIMS:

The present study was designed to examine the effect of ursodeoxycholic acid as chemoprotective agent in experimental colon carcinogenesis in rats.

MATERIAL AND METHODS:

One hundred and ten 10-week-old, Sprague-Dawley rats were divided into five groups: group A (20), no treatment. Group B (20), receiving daily both ursodeoxycholic acid (UDCA) 4 mg/kg of body weight and ethanol 1.23 g/kg of body weight added to the drinking water from the beginning of the study through 24 weeks. Group C (30), receiving 18 weekly doses of dimethylhydrazine (DMH) 21 mg/kg of body weight subcutaneously from the beginning of the study, with the same doses of UDCA and ethanol as in group B. Group D (20), ethylen-diamin-tetracetic acid solution alone for 18 weeks. Group E (20), receiving the same doses of ethanol plus DMH injections as in group C. All experimental animals were sacrificed after 25-27 weeks.

RESULTS:

No tumors developed in dimethylhydrazine-free groups. No significant differences in number of tumor-free animals, number of tumors per rat, and macro-microscopic tumor findings were seen between animals in group C and animals in group E.

CONCLUSIONS:

We concluded that such an ursodeoxycholic acid supplementation did not modify colorectal carcinogenesis using a dynamic DMH-induced model in rats.

• Authors: S Pérez-Holanda, L Rodrigo, J Viñas Salas, C Piñol Felis
• Journal: Revista espanola de enfermedades digestivas (Rev Esp Enferm Dig) Vol. 99 Issue 9 Pg. 491-6 (Sep 2007) ISSN: 1130-0108 [Print] Spain
• Vernacular Title: Efecto del ácido ursodeoxicólico en un modelo experimental de cáncer de colon.
• PMID: 18052642 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholagogues and Choleretics
• Ursodeoxycholic Acid

Topics

• Animals
• Cholagogues and Choleretics (therapeutic use)
• Colonic Neoplasms (prevention & control)
• Disease Models, Animal
• Female
• Male
• Rats
• Rats, Sprague-Dawley
• Ursodeoxycholic Acid (therapeutic use)