| Abstract | Damage to DNA and RNA caused by oxidative mechanisms has been well-studied for its potential role in the development of human disease. Only recently, though, have we begun to appreciate that oxidation of the 2-deoxyribose moiety in DNA is also a determinant of the genetic toxicology of oxidative stress and inflammation, with involvement in more than just "strand breaks", such as complex DNA lesions, protein-DNA cross-links, and protein and DNA adducts. As an update to a 1992 review of 2'-deoxyribose oxidation by bleomycin and the enediynes published in Chemical Research in Toxicology [Dedon, P. C., and Goldberg, I. H. (1992) Chem. Res. Toxicol. 5, 311-332], this review focuses on recent developments in the chemical biology, bioanalytical chemistry, and genetic toxicology of 2-deoxyribose oxidation products in DNA under biologically relevant conditions. |
| Authors | Peter C Dedon
(Affiliation: Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachussetts 02139, USA. pcdedon at mit.edu)
|
| Journal | Chemical research in toxicology
(Chem Res Toxicol)
Vol. 21
Issue 1
Pg. 206-19
(Jan 2008)
ISSN: 0893-228X United States |
| PMID | 18052112
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
|
| Chemical References |
- Solvents
- Deoxyribose
- RNA
- Glutathione
- DNA
- Glutathione Transferase
|
| Topics |
- Animals
- DNA
(chemistry, drug effects)
- DNA Damage
- Deoxyribose
(chemistry)
- Glutathione
(metabolism)
- Glutathione Transferase
(metabolism)
- Humans
- Models, Chemical
- Oxidation-Reduction
- RNA
(drug effects)
- Solvents
|
