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The chemical toxicology of 2-deoxyribose oxidation in DNA.

Abstract
Damage to DNA and RNA caused by oxidative mechanisms has been well-studied for its potential role in the development of human disease. Only recently, though, have we begun to appreciate that oxidation of the 2-deoxyribose moiety in DNA is also a determinant of the genetic toxicology of oxidative stress and inflammation, with involvement in more than just "strand breaks", such as complex DNA lesions, protein-DNA cross-links, and protein and DNA adducts. As an update to a 1992 review of 2'-deoxyribose oxidation by bleomycin and the enediynes published in Chemical Research in Toxicology [Dedon, P. C., and Goldberg, I. H. (1992) Chem. Res. Toxicol. 5, 311-332], this review focuses on recent developments in the chemical biology, bioanalytical chemistry, and genetic toxicology of 2-deoxyribose oxidation products in DNA under biologically relevant conditions.
AuthorsPeter C Dedon
JournalChemical research in toxicology (Chem Res Toxicol) Vol. 21 Issue 1 Pg. 206-19 (Jan 2008) ISSN: 0893-228X [Print] United States
PMID18052112 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
Chemical References
  • Solvents
  • Deoxyribose
  • RNA
  • DNA
  • Glutathione Transferase
  • Glutathione
Topics
  • Animals
  • DNA (chemistry, drug effects)
  • DNA Damage
  • Deoxyribose (chemistry)
  • Glutathione (metabolism)
  • Glutathione Transferase (metabolism)
  • Humans
  • Models, Chemical
  • Oxidation-Reduction
  • RNA (drug effects)
  • Solvents

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