Abstract | OBJECTIVE: METHOD: RESULT: The results demonstrated that JH-1 could significantly increase PO2, reduce PCO2 of oleic acid-induced ARDS rats, increase the superoxide dismutase, decrease the malondialdehyde, nitic oxide content and the positive expression ratio of TNF-alpha, and improve the histological destruction on lung. CONCLUSION: JH-1 plays a protective role for ARDS rats induced by oleic acid. The mechanism is probably related to attenuating lipid peroxidation and decreasing NO content and the expression of TNF-alpha in lung.
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Authors | Dan Zhu, Hua-Gang Liu |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 32
Issue 18
Pg. 1913-6
(Sep 2007)
ISSN: 1001-5302 [Print] China |
PMID | 18051906
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Combinations
- Drugs, Chinese Herbal
- Protective Agents
- Tumor Necrosis Factor-alpha
- jinhuang-1
- Oleic Acid
- Nitric Oxide
- Malondialdehyde
- Superoxide Dismutase
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Topics |
- Acute Disease
- Animals
- Astragalus propinquus
(chemistry)
- Blood Gas Analysis
- Drug Combinations
- Drugs, Chinese Herbal
(isolation & purification, pharmacology, therapeutic use)
- Female
- Lonicera
(chemistry)
- Lung
(drug effects, metabolism, pathology)
- Lung Diseases
(blood, chemically induced, prevention & control)
- Male
- Malondialdehyde
(metabolism)
- Nitric Oxide
(metabolism)
- Oleic Acid
- Phytotherapy
- Plants, Medicinal
(chemistry)
- Protective Agents
(pharmacology, therapeutic use)
- Random Allocation
- Rats
- Rats, Wistar
- Superoxide Dismutase
(metabolism)
- Syndrome
- Tumor Necrosis Factor-alpha
(metabolism)
- Ziziphus
(chemistry)
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