[Artificial inhibition of the complement system].

Abstract

A great number of natural substances affect the complement system in addition to its natural regulators. Among the complement effectors, the most important are inhibitors of the activation cascade. The necessity of searching for preparations capable of a purposeful effect on complement by inhibition of single stages of the activation cascade and without influence on its other functions is connected with the current importance of use in medicine of novel therapeutic regulators of the complement system. Important directions are the search for complement inhibitors that (a) interfere with the rejection of transplants; (b) can replace C1 inhibitor in hereditary angioedema, and (c) have a high anti-inflammatory activity in the therapy of rheumatic diseases, diabetes, and other autoimmune disorders. It is expedient to use the available techniques for the directed detection of the action of medicinal substances on complement, which allow the determination of their action on the complement system at various stages of the cascade of its activation.

• Authors: L V Kozlov, O O Burdelev, S V Bureeva, A P Kaplun
• Journal: Bioorganicheskaia khimiia (Bioorg Khim) 2007 Sep-Oct Vol. 33 Issue 5 Pg. 485-510 ISSN: 0132-3423 [Print] Russia (Federation)
• PMID: 18050655 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Complement Inactivating Agents
• Complement System Proteins

Topics

• Animals
• Complement Inactivating Agents (chemistry, classification, pharmacology)
• Complement System Proteins (drug effects)
• Drug Evaluation, Preclinical (methods)
• Humans