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Anti-Saccharomyces cerevisiae antibodies in primary biliary cirrhosis.

AbstractAIM: The aim of this study was to evaluate, retrospectively, the frequency of anti-Saccharomyces cerevisiae antibodies (ASCA) in patients with primary biliary cirrhosis (PBC). METHODS: ASCA, IgG, and IgA, were determined by ELISA in sera of 95 PBC patients; 80 healthy blood donors served as controls. RESULTS: The frequency of ASCA (IgG or IgA) was significantly higher in PBC patients than in the control group (24.2% vs 3.7%, P = 0.0001). The frequency of ASCA IgG and ASCA IgA in PBC patients was also significantly higher than that found in the control group (18.9% vs 2.5%, P = 0.0006 and 11.6% vs 1.2%, P = 0.007, respectively). Six patients out of 95 (6.3%) had both ASCA IgG and ASCA IgA; in contrast, none of the control group had both isotypes (P = 0.02). There was no correlation between ASCA levels and mitochondrial autoantibodies (AMA) titres in PBC patients. CONCLUSION: We conclude that ASCA are common in patients with PBC.
AuthorsWahiba Sakly, Moncef Jeddi, Ibtissem Ghedira (Affiliation: Research Unit of Auto-immunity and Allergy (03UR/07-02), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.)
JournalDigestive diseases and sciences (Dig Dis Sci) Vol. 53 Issue 7 Pg. 1983-7 (Jul 2008) ISSN: 0163-2116 United States
PMID18049897 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Fungal
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Fungal (blood)
  • Case-Control Studies
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Liver Cirrhosis, Biliary (immunology, microbiology)
  • Male
  • Middle Aged
  • Retrospective Studies
  • Saccharomyces cerevisiae (immunology)
  • Statistics, Nonparametric