Abstract | OBJECTIVE: METHODS: Induction of genes related to apoptosis by TAC-101 or cisplatin was assessed by DNA microarray analysis. TAC-101 (8 mg/kg/day orally for 21 days), cisplatin (7 mg/kg intravenously on day 1), or a combination of both drugs at the same dosages was administered to nude mice implanted subcutaneously with RMG-I or RMG-II clear cell adenocarcinoma cells. The antitumor effect was evaluated by calculating the treated/control tumor volume ratio at 21 days after implantation. The histoculture drug response assay was also performed using fresh surgical specimens of human ovarian cancer to determine the 50% inhibitory concentration (IC50). RESULTS: Different apoptosis-related genes were induced by TAC-101 and cisplatin. Compared with control mice, the volume of both RMG-I and RMG-II tumors was significantly reduced (p<0.05) by either drug. The IC50 values of cisplatin and TAC-101 showed a significant correlation (p<0.01). CONCLUSION:
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Authors | Sachiko Ezawa, Nao Suzuki, Shinji Ohie, Atsushi Higashiguchi, Fumihito Hosoi, Kenji Kitazato, Nobuyuki Susumu, Daisuke Aoki |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 108
Issue 3
Pg. 627-31
(Mar 2008)
ISSN: 1095-6859 [Electronic] United States |
PMID | 18048092
(Publication Type: Journal Article)
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Chemical References |
- Benzoates
- TAC 101
- Trimethylsilyl Compounds
- Cisplatin
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Topics |
- Adenocarcinoma, Clear Cell
(drug therapy, pathology)
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Apoptosis
(drug effects)
- Benzoates
(administration & dosage, pharmacology)
- Cell Line, Tumor
(drug effects)
- Cisplatin
(administration & dosage, pharmacology)
- Female
- Humans
- Inhibitory Concentration 50
- Mice
- Mice, Nude
- Ovarian Neoplasms
(drug therapy, pathology)
- Trimethylsilyl Compounds
(administration & dosage, pharmacology)
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