Abstract |
Mesoporous silica materials were prepared through a novel mixed micelle-template method which was employed by alkyl polyethylene oxide (C16,E20) and C2-ceramide. X-ray diffraction patterns clearly showed the formation of mesoporous silica by contribution of mixed micelle-template up to 3/1 weight ratio (C16E20/C2- ceramide). TEM and N2 adsorption isotherms analyses indicated that the mesoporous structure was maintained even after encased C2-ceramides. However, when the weight ratio of C16E20/C2- ceramide exceeds 2/2, less ordered and irregular pore structure was observed. According to the in-vitro experiment on cancer cells such as MCF-7, HOS, and HepG2, the simultaneously encapsulated C2-ceramide shows apoptosis. Therefore, the present results could provide a new method for mesoporous material as drug delivery system.
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Authors | You-Hwan Son, Man Park, Sang Tae Kim, Jin-Ho Choy |
Journal | Journal of nanoscience and nanotechnology
(J Nanosci Nanotechnol)
Vol. 7
Issue 11
Pg. 3819-22
(Nov 2007)
ISSN: 1533-4880 [Print] United States |
PMID | 18047066
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ceramides
- Colloids
- Macromolecular Substances
- Micelles
- Silicon Dioxide
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Topics |
- Ceramides
(chemistry)
- Colloids
(chemistry)
- Crystallization
(methods)
- Macromolecular Substances
(chemistry)
- Materials Testing
- Micelles
- Molecular Conformation
- Nanostructures
(chemistry, ultrastructure)
- Nanotechnology
(methods)
- Particle Size
- Porosity
- Silicon Dioxide
(chemistry)
- Surface Properties
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