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Mixed micelle-template route to mesoporous silica.

Abstract
Mesoporous silica materials were prepared through a novel mixed micelle-template method which was employed by alkyl polyethylene oxide (C16,E20) and C2-ceramide. X-ray diffraction patterns clearly showed the formation of mesoporous silica by contribution of mixed micelle-template up to 3/1 weight ratio (C16E20/C2-ceramide). TEM and N2 adsorption isotherms analyses indicated that the mesoporous structure was maintained even after encased C2-ceramides. However, when the weight ratio of C16E20/C2-ceramide exceeds 2/2, less ordered and irregular pore structure was observed. According to the in-vitro experiment on cancer cells such as MCF-7, HOS, and HepG2, the simultaneously encapsulated C2-ceramide shows apoptosis. Therefore, the present results could provide a new method for mesoporous material as drug delivery system.
AuthorsYou-Hwan Son, Man Park, Sang Tae Kim, Jin-Ho Choy
JournalJournal of nanoscience and nanotechnology (J Nanosci Nanotechnol) Vol. 7 Issue 11 Pg. 3819-22 (Nov 2007) ISSN: 1533-4880 [Print] United States
PMID18047066 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Ceramides
  • Colloids
  • Macromolecular Substances
  • Micelles
  • Silicon Dioxide
Topics
  • Ceramides (chemistry)
  • Colloids (chemistry)
  • Crystallization (methods)
  • Macromolecular Substances (chemistry)
  • Materials Testing
  • Micelles
  • Molecular Conformation
  • Nanostructures (chemistry, ultrastructure)
  • Nanotechnology (methods)
  • Particle Size
  • Porosity
  • Silicon Dioxide (chemistry)
  • Surface Properties

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