Correlation between free thyroxin levels and left ventricular ejection fraction in Graves' disease (preliminary study).

Abstract

AIM:

to determine the correlation between free thyroid hormone level and left ventricular ejection fraction in newly diagnosed Graves' patients.

METHODS:

this is a preliminary study with an initial cross-sectional design using free thyroxine level as a parameter of thyroid hormone state and left ventricular ejection fraction (LVEF) as a parameter of left ventricular systolic function. Free thyroxine level was measured in the laboratory and the LVEF was assessed by Simpson's methods of echocardiography study.

RESULTS:

ten patients (7 men and 3 women; age 18-52 years old) were studied. Their average of fT4 was 5.75 (SD 0.96) ng/dL and their average of LVEF was 70.57 (SD 4.50)%. There was positive correlation coefficient between free thyroxine level and left ventricular ejection fraction (r=0.711, p=0.021) in newly diagnosed Graves' patients.

CONCLUSION:

in this study strong positive correlation was found between free thyroxine (fT4) and left ventricular ejection fraction (LVEF) in newly diagnosed Graves' patients.

• Authors: Arif Mansjoer, Idrus Alwi, Imam Subekti, Yoga Iwanoff Kasjmir
• Journal: Acta medica Indonesiana (Acta Med Indones) 2007 Oct-Dec Vol. 39 Issue 4 Pg. 163-8 ISSN: 0125-9326 [Print] Indonesia
• PMID: 18046061 (Publication Type: Journal Article)

Chemical References

• Thyroxine

Topics

• Adolescent
• Adult
• Cross-Sectional Studies
• Female
• Graves Disease (blood, diagnostic imaging, physiopathology)
• Humans
• Male
• Middle Aged
• Stroke Volume
• Systole
• Thyroxine (blood)
• Ultrasonography
• Ventricular Function, Left