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Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study.

Abstract
The leucine7 to proline7 (Leu7Pro) polymorphism in preproneuropeptide Y (preproNPY) has been associated with accelerated atherosclerosis and type II diabetes, both of which are obesity-related diseases. The current study evaluated the impact of obesity on the disease risk linked to the Leu7Pro polymorphism of preproNPY in 393 elderly subjects. In 6 years follow-up, the polymorphism alone did not change the risk for abnormal glucose regulation, while obesity was associated with a significant 3-fold risk (odds ratio (OR) 2.95; 95% confidence interval (CI) 1.81-4.81, P<0.001) and the Leu7Pro polymorphism-obesity interaction, with a remarkable 12-fold risk (OR 12.33; 95% CI 1.18-128.35, P<0.05). The Leu7Pro polymorphism modified significantly the 10-year incidence of cardiovascular events, causing a 7.6-fold increase in the hazard ratio (HR 7.58; 95% CI 2.87-20.03, P<0.001) in the obese but not in the nonobese subjects. The results indicate that obesity may be a pivotal factor in multiplying the disease risk associated with the Leu7Pro polymorphism in preproNPY.
AuthorsU Jaakkola, J Kallio, R J Heine, G Nijpels, L M T' Hart, J A Maassen, L M Bouter, C D A Stehouwer, J M Dekker
JournalEuropean journal of clinical nutrition (Eur J Clin Nutr) Vol. 63 Issue 1 Pg. 150-2 (Jan 2009) ISSN: 1476-5640 [Electronic] England
PMID18043699 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • Neuropeptide Y
Topics
  • Aged
  • Blood Glucose (genetics, metabolism)
  • Blood Pressure (genetics)
  • Body Mass Index
  • Body Weight (genetics)
  • Cardiovascular Diseases (genetics)
  • Diabetes Mellitus (etiology, genetics)
  • Female
  • Follow-Up Studies
  • Glucose Tolerance Test
  • Humans
  • Male
  • Neuropeptide Y (genetics)
  • Obesity (complications, genetics)
  • Polymorphism, Single Nucleotide
  • Risk Factors

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