Abstract | BACKGROUND: METHODS: The study enrolled 18 infants and children (ages 2 months to 15.6 years) scheduled for surgical repair of their ventricular septal defects. Brain natriuretic peptide levels were drawn preoperatively and then postoperatively at 1, 24, 48, and 72 hours. The amount of shunt (the ratio of pulmonary blood flow [Q(p)]/systemic blood flow [Q(s)]) through the ventricular septal defect was determined by saturation levels performed in the catheterization laboratory or intraoperatively. RESULTS: The preoperative brain natriuretic peptide levels (pg/mL) averaged 78 +/- 57, and the postoperative levels were 168 +/- 241 at 1 hour, 418 +/- 330 at 24 hours, 405 +/- 364 at 48 hours, and 391 +/- 397 at 72 hours. These differences were significant for each postoperative time point compared with preoperative values. Preoperative brain natriuretic peptide and the Q(p)/Q(s) were significantly correlated (age-adjusted R(2) = 0.33, p < 0.001). CONCLUSIONS:
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Authors | Richard D Mainwaring, Carol Parise, Stanley B Wright, Andrew L Juris, Robert A Achtel, Hessam Fallah |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 84
Issue 6
Pg. 2066-9
(Dec 2007)
ISSN: 1552-6259 [Electronic] Netherlands |
PMID | 18036937
(Publication Type: Journal Article)
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Chemical References |
- Natriuretic Peptide, Brain
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Topics |
- Adolescent
- Child
- Child, Preschool
- Female
- Heart Septal Defects, Ventricular
(blood, surgery)
- Humans
- Infant
- Male
- Natriuretic Peptide, Brain
(blood)
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