Isolated thrombocytopenia in children: thinking beyond idiopathic thrombocytopenic purpura and leukaemia.

Abstract

The commonest cause of isolated thrombocytopenia in an otherwise well child is idiopathic thrombocytopenic purpura (ITP). The inherited thrombocytopenias such as Bernard-Soulier syndrome are rare but often misdiagnosed as ITP owing to a similar clinical presentation. We describe a child with Bernard-Soulier syndrome who presented with isolated thrombocytopenia, mimicking ITP. Features which help to differentiate these two conditions are discussed with a brief literature review.

• Authors: Radhakrishnan Kottayam, Gillian Rozenberg, Tim Brighton, Richard J Cohn
• Journal: Journal of paediatrics and child health (J Paediatr Child Health) Vol. 43 Issue 12 Pg. 848-50 (Dec 2007) ISSN: 1034-4810 [Print] Australia
• PMID: 18036021 (Publication Type: Journal Article)

Topics

• Bernard-Soulier Syndrome (physiopathology)
• Child, Preschool
• Diagnosis, Differential
• Humans
• Leukemia (diagnosis)
• Male
• New South Wales
• Thrombocytopenia (diagnosis, etiology)