Abstract |
The objective of the study was to determine the predisposing factors and incidence of toxicity among AIDS patients treated with a nevirapine (NVP)-based regimen in clinical practice. A retrospective cohort study of representative samples of AIDS patients treated with a NVP-based regimen was performed. A total of 206 adult HIV/ AIDS cases with median age (IQR) 33 years (range, 29-38 years), 51% male, treated between January 2004-December 2005, were included. Most (92.2%) of the patients were naïve to antiretroviral drug. The incidence of NVP toxicity was 1.09/100 person-months. The median onset time was 4 weeks post NVP initiation (2.57 weeks for skin toxicity and 12.43 weeks for hepatic toxicity). History of drug allergy and NVP toxicity were significantly associated (p = 0.006), as were sulfamethoxazole allergy and toxicity (p = 0.015). Regarding concomitant medication, concurrent anti-tuberculosis drugs significantly increased the risk of NVP associated liver toxicity (p = 0.001). Therefore, it is important to monitor adverse events from NVP, including liver function tests among HIV/ AIDS patients with history of drug allergy, especially against sulfamethoxazole, and those concurrently treated with antituberculosis drugs.
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Authors | Somsit Tansuphaswadikul, Saw Eindani Aung, Benjaluck Phonrat, Jaranit Kaewkungwal, Punnee Pitisuttithum, Wirach Maek-a-nantawat |
Journal | Asian Pacific journal of allergy and immunology
(Asian Pac J Allergy Immunol)
2007 Jun-Sep
Vol. 25
Issue 2-3
Pg. 147-54
ISSN: 0125-877X [Print] Thailand |
PMID | 18035802
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-HIV Agents
- Antitubercular Agents
- Nevirapine
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Topics |
- AIDS-Related Opportunistic Infections
(epidemiology)
- Adult
- Anti-HIV Agents
(adverse effects, therapeutic use)
- Antitubercular Agents
(therapeutic use)
- CD4 Lymphocyte Count
- Causality
- Cohort Studies
- Drug Eruptions
(etiology)
- Drug Hypersensitivity
(complications)
- Female
- HIV
- HIV Infections
(complications, drug therapy, immunology, virology)
- Humans
- Liver
(drug effects)
- Male
- Nevirapine
(adverse effects, therapeutic use)
- Retrospective Studies
- Tuberculosis
(complications)
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