HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Is anterior temporal lobectomy a precipitating factor for transient global amnesia?

Abstract
Little is known about the pathophysiology of transient global amnesia (TGA) and how it is related to epilepsy. We report here five typical episodes of TGA, each occurring several years after surgery for epilepsy. In all cases, patients were seizure-free after a surgery consisting of anterior temporal lobectomy for refractory medial temporal lobe epilepsy associated with hippocampal sclerosis (n = 4) or linked with a dysembryoplastic neuroepithelial tumour (n = 1). Investigations, including MRI or CT scan, angio-MRI or echocardiogram or vascular echo Doppler, excluded a vascular origin. Using accepted criteria to distinguish between TGA and epileptic amnesic attacks--the typical clinical presentation, the long duration of the episode, the absence of other symptoms associated with seizures and the absence of recurrence--it is evident that these patients suffered a TGA. These studies suggest that hippocampal resection carried out therapeutically in some epileptic patients may be a precipitating factor for TGA.
AuthorsS Dupont, S Samson, M Baulac
JournalJournal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 79 Issue 3 Pg. 309-11 (Mar 2008) ISSN: 1468-330X [Electronic] England
PMID18032454 (Publication Type: Case Reports, Journal Article)
Topics
  • Adult
  • Aged
  • Amnesia, Transient Global (diagnosis, etiology)
  • Anterior Temporal Lobectomy (adverse effects)
  • Electroencephalography
  • Epilepsy, Temporal Lobe (surgery)
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: